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Setting CALIBER (Clinic Al research using LInked Bespoke studies and Electronic health Records).

Participants 1 937 360 adults (51% women), aged ≥30 who were free from cardiovascular disease at baseline.

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Non-drinking was associated with an increased risk of unstable angina (hazard ratio 1.33, 95% confidence interval 1.21 to 1.45), myocardial infarction (1.32, 1.24 to1.41), unheralded coronary death (1.56, 1.38 to 1.76), heart failure (1.24, 1.11 to 1.38), ischaemic stroke (1.12, 1.01 to 1.24), peripheral arterial disease (1.22, 1.13 to 1.32), and abdominal aortic aneurysm (1.32, 1.17 to 1.49) compared with moderate drinking (consumption within contemporaneous UK weekly/daily guidelines of 21/3 and 14/2 units for men and women, respectively).

Heavy drinking (exceeding guidelines) conferred an increased risk of presenting with unheralded coronary death (1.21, 1.08 to 1.35), heart failure (1.22, 1.08 to 1.37), cardiac arrest (1.50, 1.26 to 1.77), transient ischaemic attack (1.11, 1.02 to 1.37), ischaemic stroke (1.33, 1.09 to 1.63), intracerebral haemorrhage (1.37, 1.16 to 1.62), and peripheral arterial disease (1.35; 1.23 to 1.48), but a lower risk of myocardial infarction (0.88, 0.79 to 1.00) or stable angina (0.93, 0.86 to 1.00).I know there’s always been sex activity going on, outside marriages, but, there was a time when people wouldn’t feel so free to talk about all of that.Is this guy a serious candidate or some gadfly type politician??Conclusions Heterogeneous associations exist between level of alcohol consumption and the initial presentation of cardiovascular diseases.This has implications for counselling patients, public health communication, and clinical research, suggesting a more nuanced approach to the role of alcohol in prevention of cardiovascular disease is necessary. The relation between alcohol consumption and cardiovascular disease is both complex and controversial.12 There have been multiple systematic reviews and meta-analyses of the association between consumption and aggregated cardiovascular disease,1234567 as well as cardiovascular traits.189 Most have shown that, compared with non-drinking, moderate levels of alcohol intake are associated with a lower risk of morbidity and mortality from cardiovascular disease, as well as more favourable cardiovascular health profiles in general.Main outcome measures 12 common symptomatic manifestations of cardiovascular disease, including chronic stable angina, unstable angina, acute myocardial infarction, unheralded coronary heart disease death, heart failure, sudden coronary death/cardiac arrest, transient ischaemic attack, ischaemic stroke, intracerebral and subarachnoid haemorrhage, peripheral arterial disease, and abdominal aortic aneurysm.

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